2-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramide → 4-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid-N-hydroxyamide

HRID 1005897Notes

Reaction equation

HRID 1005897 reaction equation
O1C=CC=C1C1C=CC(N2CCN(S(CC(C(C)C)C([NH:25][OH:26])=O)(=O)=O)CC2)=CC=1.[N:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]2[CH:41]=[CH:40][C:39]([N:42]3[CH2:47][CH2:46][N:45]([S:48]([CH2:51][C:52]4([C:58]([OH:60])=O)[CH2:57][CH2:56][O:55][CH2:54][CH2:53]4)(=[O:50])=[O:49])[CH2:44][CH2:43]3)=[CH:38][CH:37]=2)[CH:31]=1>>[OH:26][NH:25][C:58]([C:52]1([CH2:51][S:48]([N:45]2[CH2:46][CH2:47][N:42]([C:39]3[CH:38]=[CH:37][C:36]([C:32]4[CH:31]=[N:30][CH:35]=[CH:34][CH:33]=4)=[CH:41][CH:40]=3)[CH2:43][CH2:44]2)(=[O:49])=[O:50])[CH2:57][CH2:56][O:55][CH2:54][CH2:53]1)=[O:60]

Participants

3

Reactant 2

HCID 99319692-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramideHCID 226467164-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid

Product 1

HCID 102763494-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid-N-hydroxyamideYield 94%

Procedure

Prepared according to the method for the preparation of 2-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramide, from 4-[4-(4-pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid (0.20 g), to yield the title compound as a white solid (0.19 g, 94%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a4d8aa7a218c48f9a5b5db1375f2056e
Source dataset
uspto-grants-2004_09
Patent number
US06787536B2

Reaction notes

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