HuagongsheHuagongshe Chemistry Print Report · For research reference only
Furan-2-boronic acid → 4-[4-(4-Furan-2-ylphenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4carboxylic acid-N-hydroxyamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Furan-2-boronic acid | HCID 2734357 | — |
| Reactant | 2-[4-(4-Furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-3-methylbutyric acid | HCID 22646742 | — |
| Reactant | 4-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid hydroxyamide | HCID 86584769 | — |
| Product | 4-[4-(4-Furan-2-ylphenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4carboxylic acid-N-hydroxyamide | HCID 86584770 | 14% |
Reaction Steps
Prepared according to the method for the preparation 2-[4-(4-furan-2-ylphenyl)-piperazine-1-sulfonylmethyl]-3-methylbutyric acid, from 4-[4-(4-bromophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid hydroxyamide (0.249 g) and furan-2-boronic acid (0.066 g), to give the title compound as a cream solid (0.034 g, 14%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787536B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-2620727dbc46466da7b92efa8302ece0 |
| Source note | uspto-grants-2004_09 |