Thionyl Chloride → HCID 15895805, compound

Participants

Reaction Steps

1 equivalent of 3-[4-(3-chloro-4-methoxybenzyl-amino)benzothieno[2,3-d]pyrimidin-2-yl]propionic acid and 1.2 equivalents of thionyl chloride are stirred in dichloromethane for 2 hours. The solvent is removed and 3-[4-(3-chloro-4-methoxybenzylamino)benzothieno[2,3-d]-pyrimidin-2-yl]propionyl chloride is obtained. The mixture is transferred to aqueous ammonia, stirred for one hour and, after customary working up, 3-[4-(3-chloro-4-methoxybenzylamino)benzothieno[2,3-d]pyrimidin-2-yl]propionamide is obtained.

Provenance & Evidence