4-Chloro-2,6-dimethoxypyrimidine → 1-[4-[7-(2,6-dimethoxypyrimidin-4-yl)-4-(3-methylmorpholin-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea

HRID 100595Notes

Reaction equation

HRID 100595 reaction equation
[CH2:1]([CH3:2])[NH:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10](-[c:13]2[n:14][c:15]([N:23]3[CH:24]([CH3:29])[CH2:25][O:26][CH2:27][CH2:28]3)[c:16]3[c:17]([n:18]2)[CH2:19][NH:20][CH2:21][CH2:22]3)[cH:11][cH:12]1.[CH3:30][O:31][c:32]1[n:33][c:34]([O:39][CH3:40])[cH:35][c:36]([Cl:38])[n:37]1>>[CH2:1]([CH3:2])[NH:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10](-[c:13]2[n:14][c:15]([N:23]3[CH:24]([CH3:29])[CH2:25][O:26][CH2:27][CH2:28]3)[c:16]3[c:17]([n:18]2)[CH2:19][N:20]([c:36]2[cH:35][c:34]([O:39][CH3:40])[n:33][c:32]([O:31][CH3:30])[n:37]2)[CH2:21][CH2:22]3)[cH:11][cH:12]1

Participants

3

Reactant 2

HCID 806004-Chloro-2,6-dimethoxypyrimidineHCID 666875921-Ethyl-3-[4-[4-(3-methylmorpholin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl]phenyl]urea

Product 1

HCID 671772611-[4-[7-(2,6-dimethoxypyrimidin-4-yl)-4-(3-methylmorpholin-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea

Sources & evidence

ORD record
ord-843a4a894dc54853a7d8ca31fe25fc17
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…