4-Bromopyridine → HCID 9948724, compound

Participants

Reaction Conditions

Reaction Steps

0.47 g of the compound obtained in Example 13a, 0.30 g of 4-bromo-pyridine, 0.80 g of KOH and 0.20 g of 18-crown-6-ether were added to 20 ml of dimethyl sulfoxide and heated to 150° C. for 8 hours. The reaction mixture was cooled, then added with water and extracted with ethyl acetate. The extract was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate) to obtain 0.19 g of the title compound (yield: 30%).

Provenance & Evidence