Sodium Hydroxide → HCID 22675452, compound

Participants

Reaction Steps

0.62 g of the compound obtained in Example 14b was dissolved in 10 ml of t-BuOH, added dropwise slowly with a mixed solution (30 ml) of 1.92 g of KMnO4 and 50 ml of 0.1 N NaOH, and then the mixture was stirred for 1 hour. The reaction mixture was extracted three times with chloroform, and the organic layer was dried over sodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane) to obtain 0.34 g of the title compound (yield: 61%).

Provenance & Evidence