2-Chloropyridine → HCID 22675455, compound

Participants

Reaction Conditions

Reaction Steps

218 mg of the compound obtained in Example 16a, 115 mg of 2-chloropyridine, 200 mg of KOH and 50 mg of 18-crown-6-ether were added to 15 ml of DMSO and the mixture was heated to 150° C. for 8 hours. The reaction mixture was cooled, then added with water and extracted with ethyl acetate. The extract was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate) to obtain 150 mg of the title compound (yield: 51%).

Provenance & Evidence