Potassium Hydroxide → HCID 9840367, compound

Participants

Reaction Conditions

Reaction Steps

0.5 g of the compound obtained in Example 26a, 0.4 g of 4-bromopyridine hydrochloride, 0.38 g of potassium hydroxide and 0.2 g of 18-crown-6-ether were added to 10 ml of DMSO and the mixture was heated to 150° C. with stirring for 6 hours. After cooling, the reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with water and dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate:methylene chloride=1:3) and crystallized from acetonitrile to obtain 0.14 g of the title compound (yield: 22%).

Provenance & Evidence