Water → HCID 22675442, compound

Participants

Reaction Steps

0.2 g of (Compound 1) was dissolved in 0.8 ml of dimethylacetamide and 1.6 ml of acetonitrile, added with 0.14 ml of triethylamine and then added with 74 mg of propionyl chloride at 50° C. After 30 minutes, the reaction mixture was cooled and added with water and extracted with ethyl acetate. The organic layer was washed with water and dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by using a silica gel column (ethyl acetate:methylene chloride=1:5) and crystallized from ethyl acetate:hexane to obtain 0.17 g of the title compound (yield: 72%).

Provenance & Evidence