Sodium Hydroxide → HCID 22674310, compound

Participants

Reaction Steps

To a solution of 1.60 g (4.43 mmol) methyl-(2-methylsulfanyl-4-o-tolyloxy-pyrimidin-5-yl)-carbamic acid tert.-butyl ester in 20 ml CH2Cl2 2 ml trifluoracetic acid was added and the reaction mixture stirred for 2 hrs. at 40°. The reaction mixture was poured into ice-water and the pH of the solution adjusted to 10 with 1N NaOH solution. The aqueous phase was extracted three times with 80 ml CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and evaporated to give 1.10 g (95%) methyl-(2-methylsulfanyl-4-o-tolyloxy-pyrimidin-5-yl)-amine as a white solid, MS (EI): 261 (M+).

Provenance & Evidence