Methyl iodide → 4-[N-(2-Benzyloxy-5-bromophenethyl)-N-methylamino]benzoic Acid

HRID 1006050Notes

Reaction equation

HRID 1006050 reaction equation
C(OC1C=CC(Br)=CC=1CCNC1C=CC(C(OCC)=O)=CC=1)C1C=CC=CC=1.[CH2:30]([O:37][C:38]1[CH:58]=[CH:57][C:56]([Br:59])=[CH:55][C:39]=1[CH2:40][CH2:41][N:42]([C:44]1[CH:54]=[CH:53][C:47]([C:48]([O:50]CC)=[O:49])=[CH:46][CH:45]=1)[CH3:43])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.CI>>[CH2:30]([O:37][C:38]1[CH:58]=[CH:57][C:56]([Br:59])=[CH:55][C:39]=1[CH2:40][CH2:41][N:42]([C:44]1[CH:45]=[CH:46][C:47]([C:48]([OH:50])=[O:49])=[CH:53][CH:54]=1)[CH3:43])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 22675492ethyl 4-[N-(2-benzyloxy-5-bromophenethyl)-N-methylamino]benzoateHCID 22675521ethyl 4-[N-(2-benzyloxy-5-bromophenethyl)amino]benzoate

Product 1

HCID 226754934-[N-(2-Benzyloxy-5-bromophenethyl)-N-methylamino]benzoic Acid

Procedure

Ethyl 4-[N-(2-benzyloxy-5-bromophenethyl)amino]benzoate was converted to ethyl 4-[N-(2-benzyloxy-5-bromophenethyl)-N-methylamino]benzoate using a similar method to that described in Example 41(D) except methyl iodide was used in place of iodoethane.

Sources & evidence

ORD record
ord-15f479a5e6774363abecd0ff2d70645e
Source dataset
uspto-grants-2004_09
Patent number
US06787562B2

Reaction notes

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