反应详情

温度

60 °C

At room temperature, 4N-hydrogen chloride/dioxane (35 mL) was added dropwise to a solution of the crude product (18.3 g) of N-tert-butoxycarbonyl-4-(2-bromo-5-methoxy-benzyl)piperidine in acetic acid (50 mL), and the resulting mixture was stirred at 60° C. for 1 hour. The solvent was distilled off and ethyl acetate was added to the residue to effect crystallization. The crystals were collected by filtration, washed with ethyl acetate and then dried to obtain 12.9 g (40.2 mmol) of 4-(2-bromo-5-methoxybenzyl)piperidine hydrochloride.

1. distillationThe solvent was distilled off
2. additionethyl acetate was added to the residue
3. customcrystallization
4. filtrationThe crystals were collected by filtration
5. washwashed with ethyl acetate
6. customdried