Triethylamine → HCID 22675353, compound

Participants

Reaction Steps

A solution (5 ml) of 3-[4-(2-bromo-5-methoxybenzyl)-1-piperidinyl]propylamine (400.0 mg, 1.179 mmol), methyl 2-(bromomethyl)benzoate (400.0 mg, 1.746 mmol) and triethylamine (200.0 mg, 1.976 mmol) in toluene was stirred with heating under reflux for 5 hours. The reaction solution was diluted with ethyl acetate and the triethylamine hydrobromide produced during the reaction was filtered off. Then, the solvent was distilled off under reduced pressure and the residue was purified by a silica gel column chromatography (hexane/ethyl acetate=3/1˜ethyl acetate˜triethylamine/ethyl acetate=1/19) to obtain the title compound (439.3 mg, 0.960 mmol) in a yield of 82%.

Provenance & Evidence