HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1006085Generated: October 30, 2026
Trifluoroacetic acid → d-Valine benzyl ester trifluoroacetic acid salt
https://huagongshe.com/reaction/1006085
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-benzyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate | HCID 11243734 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | d-Valine benzyl ester trifluoroacetic acid salt | HCID 69764497 | — |
Reaction Steps
N-Tert-butoxycarbonyl-D-valine benzyl ester (70.7 g, 0.23 mol) was dissolved in a mixture of trifluoroacetic acid and methylene chloride (150 mL in 1:4 ratio) and the reaction mixture was heated at 50-60° C. After 6 h, the reaction mixture was concentrated to give D-valine benzyl ester trifluoroacetic acid salt (156.8 g) as a viscous oil which was converted to the free amine just prior to use.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06787559B2 |
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| Source dataset | uspto-grants-2004_09 |
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| ORD ID | ord-a33619ebab044081af2556e45ca2c4bf |
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| Source note | uspto-grants-2004_09 |
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