Nitric Acid → HCID 22339380, compound

HRID 1006206Notes

Reaction equation

HRID 1006206 reaction equation
[N+:1]([O-:4])(O)=[O:2].[Cl:5][C:6]1[CH:7]=[C:8]([N:22]2[C:27](=[O:28])[NH:26][C:25](=[O:29])[CH:24]=[N:23]2)[CH:9]=[C:10]([Cl:21])[C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1.O>C(O)(=O)C>[Cl:5][C:6]1[CH:7]=[C:8]([N:22]2[C:27](=[O:28])[NH:26][C:25](=[O:29])[CH:24]=[N:23]2)[CH:9]=[C:10]([Cl:21])[C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([N+:1]([O-:4])=[O:2])[CH:14]=1

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 22339608HCID 22339608, compound

Product 1

HCID 22339380HCID 22339380, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
0 °C

Procedure

To a cooled (0° C.), stirred solution of nitric acid (20 mL) in acetic acid (65 mL) was added 2-[3,5-dichloro-4-(4-methoxy-phenoxy)-phenyl]-2H-[1,2,4]triazine-3,5-dione (5.0 g) and the resulting mixture was allowed to stir at ambient temperature for 1.5 h. The resulting solution was poured into 400 mL of water, the resulting solids filtered and dried to afford the title compound of Step A as a yellow solid, 5.1 g. MS Calc.:425.2; Found: 422.9.

Workup

  1. filtrationthe resulting solids filtered
  2. customdried

Sources & evidence

ORD record
ord-da4b65f421684b2f864b2a09f83be920
Source dataset
uspto-grants-2004_09
Patent number
US06787652B1

Reaction notes

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