Chlorosulfonic acid → HCID 22339649, compound

HRID 1006218Notes

Reaction equation

HRID 1006218 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[CH:8]=[C:9]([N:23]2[C:28](=[O:29])[NH:27][C:26](=[O:30])[CH:25]=[N:24]2)[CH:10]=[C:11]([Cl:22])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1>>[Cl:6][C:7]1[CH:8]=[C:9]([N:23]2[C:28](=[O:29])[NH:27][C:26](=[O:30])[CH:25]=[N:24]2)[CH:10]=[C:11]([Cl:22])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:15]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 22339608HCID 22339608, compound

Product 1

HCID 22339649HCID 22339649, compound

Conditions

Temperature
0 °C

Procedure

To a cooled (0° C.), stirred solution of chlorosulfonic acid (1 mL) was added 2-[3,5-dichloro-4-(4-methoxy-phenoxy)-phenyl]-2H-[1,2,4]triazine-3,5-dione (0.6 g). After 30 min, the resulting brown solution was poured over ice and the resulting mixture was allowed to stir at ambient temperature for 30 min, the solids filtered and dried in vacuo to afford the title compound of Step A as a colorless solid, 0.7 g.

Workup

  1. additionthe resulting brown solution was poured over ice
  2. filtrationthe solids filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-37330677388a4c8a86f70098273abf5d
Source dataset
uspto-grants-2004_09
Patent number
US06787652B1

Reaction notes

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