Hydrochloric Acid → HCID 22676859, compound

Participants

Reaction Steps

To a solution of 136 mg (0.173 mmol) of 1,3-bis[4-[4-(3,5-dimethoxy-4-methylthiophenyl)benzoyl]-1-piperazinyl]propane in chloroform (3 mL) stirred in an ice bath was added 0.11 mL (0.44 mmol) of a 4 mol/L ethyl acetate solution of hydrogen chloride, and the mixture was concentrated under reduced pressure. Methanol-diethyl ether was added and the precipitates were pulverized and collected by filtration to afford 105.0 mg of 1,3-bis[4-[4-(3,5-dimethoxy-4-methylthiophenyl)benzoyl]-1-piperazinyl]propane dihydrochloride as a colorless amorphous powder (yield 71%).

Provenance & Evidence