Diethyl Ether → HCID 22676855, compound

Participants

Reaction Steps

To a solution of 3.28 g (4.20 mmol) of 1,3-bis[4-[4-(4-ethoxy-3,5-dimethoxyphenyl) benzoyl]-1-piperazinyl]propane in methanol (10 mL) was added a solution of 808.2 mg (8.41 mmol) of methanesulfonic acid in methanol (5 mL). After addition of diethyl ether (15 mL), the mixture was stirred for 30 minutes at room temperature and for 30 minutes in an ice bath. Precipitates were collected by filtration and washed with methanol-diethyl ether (2:3) and diethyl ether to afford 3.29 g of 1,3-bis[4-[4-(4-ethoxy-3,5-dimethoxyphenyl)benzoyl]-1-piperazinyl]propane dimethanesulfonate as a colorless crystalline powder (yield: 80%). mp: 245.0° C. (decomposed)

Provenance & Evidence