HCID 22676789, compound → HCID 22676765, compound

Participants

Reaction Steps

A solution of ethyl 5-(benzyloxy)-3-(4-ethoxyphenyl)-1-(4-fluorobenzyl)-1H-indole-2-carboxylate (Example 69, 4.7 g, 9.0 mmol) in ethyl acetate (15 mL) was added to a suspension of 10% palladium on charcoal (2.0 g) in ethyl acetate (10 mL). The mixture was placed under an atmosphere of hydrogen (1 atm) and stirred for 16 h. The reaction was filtered through a pad of Celite using ethyl acetate to rinse. Evaporation of the filtrate left 3.5 g (90%) of the desired product. The product had: 1H NMR (300 MHz, acetone-D6) δ 7.98 (s, 1 H), 6.89-7.42 (m, 11 H), 5.81 (s, 2 H), 4.03-4.19 (m, 4 H), 1.41 (t, 3 H), 1.04 (t, 3 H).

Provenance & Evidence