Hydrochloric Acid → HCID 69818612, compound

Participants

Reaction Steps

Tert-Butyl (3RS,4aSR,8aRS)-3-benzhydryloctahydroquinoxaline-1-carboxylate (100 mg) was dissolved in hydrogen chloride (5 ml, 4N solution in ethyl acetate) and the mixture was stirred at ambient temperature for 3 hours. The volatile materials were removed under reduced pressure to give (2RS,4aRS,8aSR)-2-benzhydryldecahydroquinoxaline dihydrochloride, which was dissolved in water and washed with ethyl acetate. The aqueous phase was adjusted to pH 9-10 and extracted with ethyl acetate three times. The combined extract was washed with brine, dried over magnesium sulfate, and concentrated in vacuo to give (2RS,4aRS,8aSR)-2-benzhydryldecahydroquinoxaline (88 mg).

Provenance & Evidence