2-(4-Fluorophenyl)-3-oxo-3-pyridin-4-yl-propionic acid methyl ester → 4-(4-Fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one

HRID 1006409Notes

Reaction equation

HRID 1006409 reaction equation
C[O:2][C:3](=[O:22])[CH:4]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[C:5](=O)[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:12][CH3:13])[N:7]=1.COC(=O)C(C1C=CC(F)=CC=1)C(=O)C1C=C[N:31]=CC=1>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([C:4]2[C:3](=[O:22])[O:2][NH:31][C:5]=2[C:6]2[CH:11]=[CH:10][N:9]=[C:8]([S:12][CH3:13])[N:7]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 109346152-(4-Fluorophenyl)-3-oxo-3-pyridin-4-yl-propionic acid methyl esterHCID 129914032-(4-Fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-3-oxo-propionic acid methyl ester

Product 1

HCID 98360464-(4-Fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one

Procedure

Using the procedure from Example 1l set forth above, substitute 2-(4-fluorophenyl)-3-oxo-3-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid methyl ester for 2-(4-fluorophenyl)-3-oxo-3-pyridin-4-yl-propionic acid methyl ester to produce the title compound.

Sources & evidence

ORD record
ord-b3c19780955f49239751a4dcc3b9996b
Source dataset
uspto-grants-2004_09
Patent number
US06790846B2

Reaction notes

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