HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-(4-Fluorophenyl)-4-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 3-(4-Fluorophenyl)-3-oxo-2-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid ethyl ester | HCID 12150542 | — |
| Product | 3-(4-Fluorophenyl)-4-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one | HCID 22349927 | — |
Reaction Steps
Using the procedure from Example 1k set forth above, substitute 3-(4-fluorophenyl)-3-oxo-2-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid ethyl ester for 2-(4-fluorophenyl)-3-oxo-3-pyridin4-yl-propiornc acid methyl ester and ethanol for pyridine to produce the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06790846B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-b68d7b8c242b4d43be7b7532fe7b03ef |
| Source note | uspto-grants-2004_09 |