Ammonium formate → HCID 10270565, compound

Participants

Reaction Steps

A mixture of 250 mg(0.54 mmole) 4-(4-benzyl-piperazin-1-yl)-1-(4-methoxybenzenesulfonyl)-1H-indole, 500 mg (8 mmole) ammonium formate and 50 mg 10% Pd-C in 20 mL ethanol was heated under reflux for 2 hours. The mixture was filtered through Whatman GF/B and the filtrate was concentrated under reduced pressure. The residue was partitioned between 10 mL 10% sodium carbonate and 25 mL ethyl acetate. The organic phase was washed with 5 ml water, 5 mL saturated sodium chloride, dried (magnesium sulfate) and concentrated under reduced pressure. The 1-(4-Methoxy-benzenesulfonyl)-4-piperazin-1-yl-1H-indole (3) was isolated as the hydrochloride salt from methanol-ethyl acetate-ether, 128 mg, m.p. 209-210° C.

Provenance & Evidence