反应详情

A solution of 125 mg (0.28 mmole) 4-(1-benzenesulfonyl-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester in 2 mL trifluoroacetic acid was stored at room temperature for 10 minutes. The solution was concentrated under reduced pressure and the residue was partitioned between 3 mL 10% sodium carbonate and 20 mL ethyl acetate. The organic phase was washed with 5 mL water, dried (magnesium sulfate) and concentrated. 1-Benzenesulfonyl-4-piperazin-1-yl-1H-indole (5) was isolated as the hydrochloride salt from ethyl acetate-ethyl ether, 73 mg, M+H=342; m.p.294-295° C.

1. concentrationThe solution was concentrated under reduced pressure
2. customthe residue was partitioned between 3 mL 10% sodium carbonate and 20 mL ethyl acetate
3. washThe organic phase was washed with 5 mL water
4. dry with materialdried (magnesium sulfate)
5. concentrationconcentrated