Hydrochloric Acid → HCID 10159085, compound

Participants

Reaction Steps

To a suspension of 0.102 g (0.2 mmole) 4-(1-benzenesulfonyl-3-bromo-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester in 3 mL ethanol was added 2 mL concentrated hydrochloric acid. The mixture was heated under reflux until all solid has dissolved. The mixture was concentrated to dryness under reduced pressure and the residue was recrystallized from methanol/ether to provide 0.082 g of 1-benzenesulfonyl-3-bromo-4-piperazin-1-yl-1H-indole (31), mp 304-305° C., as hydrochloride salt.

Provenance & Evidence