Sulfuric acid magnesium salt (1:1) → HCID 22671411, compound

Participants

Reaction Steps

A suspension of lithium aluminum hydride (9.7 mg) in tetrahydrofuran (0.3 ml) was added with a solution of the 1-[3-(4-diethylcarbamoylphenyl)-3-(3-methoxy-phenyl)propyl]-4-(1H-benzimidazol-1-yl)piperidine (67.1 mg) obtained in Example 11 dissolved in toluene (1.2 ml) and stirred at room temperature for 18 hours. The reaction mixture was added with one drop of water and one drop of 5 N aqueous sodium hydroxide and further stirred at room temperature for 1 hour. The reaction mixture was added with anhydrous magnesium sulfate and filtered, and then the solvent was evaporated under reduced pressure to obtain 64.9 mg of the title compound. Yield: 99%.

Provenance & Evidence