4-Acetamidophenylboronic acid → HCID 59717936, compound

HRID 1006483Notes

Reaction equation

HRID 1006483 reaction equation
[CH2:1]([C:8]1[C:17]2[C:12](=[C:13]([I:19])[C:14](I)=[CH:15][CH:16]=2)[C:11](=[O:20])[NH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]([NH:24][C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1)(=[O:23])[CH3:22]>>[C:21]([NH:24][C:25]1[CH:30]=[CH:29][C:28]([C:14]2[C:13]([I:19])=[C:12]3[C:17](=[CH:16][CH:15]=2)[C:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:9][NH:10][C:11]3=[O:20])=[CH:27][CH:26]=1)(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 27346574-Acetamidophenylboronic acidHCID 12458186HCID 12458186, compound

Product 1

HCID 59717936HCID 59717936, compound

Procedure

1-Benzyl-5,6-diiodo-phthalazin-4-one (Indian J. Chem. 16B, 1978, 301-304) is reacted analogously to Example 1/f. with 1 equivalent of 4-acetamidophenyl-boronic acid. The title compound is obtained in pure form by chromatography on silica gel.

Sources & evidence

ORD record
ord-e30854ca73134ccc840efb6e641992e2
Source dataset
uspto-grants-2004_09
Patent number
US06790858B2

Reaction notes

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