Pyridine → HCID 178514143, compound

Participants

Reaction Conditions

Reaction Steps

6-Amino-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone (10.5 g) [preparation as described in WO 9635678] and potassium thiocyanate (25 g) in N,N-dimethylformamide (200 ml) were heated together at 65° C. Pyridine (6.3 ml) was added and the solution cooled to 5° C. Bromine (2.2 ml) was added slowly and the reaction mixture stirred for 2 hours at 5-10° C. The reaction mixture was poured onto ice water, stirred for 1 hour and the solid was isolated by filtration. After washing with water and ether, a pure sample was obtained after trituration with hot methanol.

Provenance & Evidence