1-(Bromomethyl)-2,3-difluoro-benzene → HCID 178508256, compound

HRID 1006492Notes

Reaction equation

HRID 1006492 reaction equation
CC(C)([O-])C.[K+].[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[NH:14][C:13](=[S:17])[NH:12][C:11]=2[N:18]=1.[F:19][C:20]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22]Br>CS(C)=O>[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[N:14]=[C:13]([S:17][CH2:22][C:21]3[CH:24]=[CH:25][CH:26]=[C:27]([F:28])[C:20]=3[F:19])[NH:12][C:11]=2[N:18]=1

Participants

5

Reactant 3

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 114583092-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-oneHCID 23665647Potassium tert-butoxide

Product 1

HCID 178508256HCID 178508256, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Potassium t-butoxide solution (0.45 ml of 1M solution in tetrahydrofuran) was added to a stirred solution of 2-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-one (0.09 g) [Cited: Indian J. Chem., Sect. B (1989), 28B(11), 964-5.] and 2,3-difluorobenzyl bromide in dimethyl sulphoxide (2 ml). After stirring for 3 days, the reaction mixture was poured onto water to give and the subtitle compound, isolated by filtration.

Workup

  1. additionthe reaction mixture was poured onto water
  2. customto give

Sources & evidence

ORD record
ord-a7a75b0f10e0404594d76a55bd7a4c8b
Source dataset
uspto-grants-2004_09
Patent number
US06790850B1

Reaction notes

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