(R)-(+)-1-Boc-3-aminopyrrolidine → HCID 86635802, compound

HRID 1006498Notes

Reaction equation

HRID 1006498 reaction equation
[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.Cl[C:15]1[C:16]2[S:33][C:32]([NH2:34])=[N:31][C:17]=2[N:18]=[C:19]([S:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:24]=2[F:30])[N:20]=1>>[NH2:34][C:32]1[S:33][C:16]2[C:15]([NH:1][C@@H:2]3[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]3)=[N:20][C:19]([S:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:24]=3[F:30])=[N:18][C:17]=2[N:31]=1

Participants

3

Reactant 2

HCID 854070(R)-(+)-1-Boc-3-aminopyrrolidineHCID 112216507-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

Product 1

HCID 86635802HCID 86635802, compound

Procedure

Prepared by the method of example 18 step a) using (R)-3-amino-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester and the product of example 4 step b).

Workup

  1. customPrepared by the method of example 18 step a)

Sources & evidence

ORD record
ord-ae610154b80c4c8287d25d39cf78e106
Source dataset
uspto-grants-2004_09
Patent number
US06790850B1

Reaction notes

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