HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1006510Generated: October 30, 2026
Water → (2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol
https://huagongshe.com/reaction/1006510
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-(Benzylthio)-7-chloro[1,3]thiazolo[4,5-d]pyrimidin-2-amine | HCID 11278274 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | (2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol | HCID 11857680 | 32% |
Reaction Steps
The product of example 1 step c) (25.0 g), D-Alaninol (12.3 g) and diisopropylethylamine (26.0 g) were diluted in N-methylpyrrolidinone (250 ml) and stirred at 100° C. for 24 h before cooling and pouring the reaction mixture into H2O (2.5 l). The precipitate was filtered and dried in vacuo before being preabsorped onto silica gel. Chromatography using EtOAc. 4% MeOH/EtOAc as eluents afforded the desired product as a yellow solid (9.0 g. 32%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06790850B1 |
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| Source dataset | uspto-grants-2004_09 |
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| ORD ID | ord-fbe4f8d2d0b64ee7a036560f4cb4c28c |
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| Source note | uspto-grants-2004_09 |
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