反应详情

Isoamyl nitrite (0.3 ml) was added to a suspension of the product of example 32 step c) (0.23 g) in bromoform (15 ml) and acetonitrile (15 ml) at 50° C. Stirring was maintained for 10 min before concentrating to approximately, 3 ml. The residue was purified by column chromatography using 20% EtOAc/DCM as eluent to yield the subtitle compound as a yellow solid (102 mg, 38%).

1. customat 50° C
2. temperaturewas maintained for 10 min
3. concentrationbefore concentrating to approximately, 3 ml
4. customThe residue was purified by column chromatography