反应详情

To a solution of 2-nitro-4-chloroaniline (500 mg) and pyridine (2.1 ml in methylene chloride (10 ml), benzenesulfonylchloride (1.2 ml) was added dropwise at 0° C. under an atmosphere of argon. The reaction mixture was stirred for 3 days at room temperature. To the reaction mixture, water was added. The mixture was extracted with ethyl acetate. The organic layer was washed, dried over and concentrated under the reduced pressure. The reside was recrystallized from AcOEt-hexane mixture solvent to give the by-product. The mother liquor was concentrated under the reduced pressure. The residue was purified on silica gel column chromatography (AcOEt-hexane) and recrystallized from AcOEt-hexane mixture solvent to give the title compound (175 mg) having the following physical data.

1. extractionThe mixture was extracted with ethyl acetate
2. washThe organic layer was washed
3. customdried over and
4. concentrationconcentrated under the reduced pressure
5. customThe reside was recrystallized from AcOEt-hexane mixture solvent
6. customto give the by-product
7. concentrationThe mother liquor was concentrated under the reduced pressure
8. customThe residue was purified on silica gel column chromatography (AcOEt-hexane)
9. customrecrystallized from AcOEt-hexane mixture solvent