HCID 23378638, compound → HCID 22672036, compound

HRID 1006560Notes

Reaction equation

HRID 1006560 reaction equation
[C:1]1([S:7]([NH:10][C:11]2[CH:18]=[CH:17][C:14]([CH2:15][OH:16])=[CH:13][C:12]=2[O:19][CH3:20])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([S:7]([NH:10][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=2[O:19][CH3:20])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 23378638HCID 23378638, compound

Product 1

HCID 22672036HCID 22672036, compoundYield 77.9%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-phenylsulfonylamino-3-methoxybenzyl alcohol (522 mg; prepared in Reference Example 43.) in methylene chloride (15 ml), manganese dioxide (3 g) was added in a stream of argon. The solution was stirred for 1 hour at room temperature. After the termination of reaction, the reaction mixture was filtered. The filtrate was concentrated to give the title compound (404 mg) having the following physical data.

Workup

  1. customAfter the termination of reaction
  2. filtrationthe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-8d3cf1a3f58448cab658eb14006a1291
Source dataset
uspto-grants-2004_09
Patent number
US06790866B2

Reaction notes

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