反应详情

To a solution of 4-chloro-2-hydroxybenzoic acid (5.0 g) in ether (50 ml), diazomethane in ether was added until the reaction was terminated at 0° C. The reaction mixture was concentrated under the reduced pressure. The residue was purified on silica gel column chromatography (hexane:AcOEt=4:1) to give the title compound (5.4 g) having the following physical data.

1. customwas terminated at 0° C
2. concentrationThe reaction mixture was concentrated under the reduced pressure
3. customThe residue was purified on silica gel column chromatography (hexane:AcOEt=4:1)