N,N-Dimethyl-4-nitro-2-sulfamoylbenzamide → 4-amino-N,N-dimethyl-2-sulfamoylbenzamide

Participants

Reaction Steps

1 g of moist Raney nickel is added to a solution of 12.5 g of 2-dimethylaminocarbonyl-5-nitrobenzenesulfonamide in 250 ml of methanol, and thorough mixing is carried out at 60° C. under a hydrogen pressure of 50 bar. After the end of uptake of hydrogen, the catalyst is separated off and the filtrate is concentrated, giving 11.0 g of desired product.

Provenance & Evidence