反应详情

温度

120 °C

The 2,6-dichloropurine (4.06 g, 21.5 mmol) was suspended in n-butanol (150 ml) and the 4 methoxybenzylamine was added (3.4 ml, 26 mmol). The solution turned clear and then cloudy a few minutes later. The solution was heated at 120° C. for 2 hr and then cooled. The n-butanol was evaporated followed by suspension of the residue in water and diethyl ether mixture. A solution of 2N NaOH (1.3 ml, 26 mmol) was added and the solution stirred for 10 min before filtration. The filtered precipitate was washed with water and a small portion of ether and then dried under vacuum. The residual liquor was left overnight and more crystals were collected the next day and washed with diethyl ether.

1. waitcloudy a few minutes
2. temperaturecooled
3. customThe n-butanol was evaporated
4. additionfollowed by suspension of the residue in water
5. washThe filtered precipitate was washed with water
6. dry with materiala small portion of ether and then dried under vacuum
7. waitThe residual liquor was left overnight
8. custommore crystals were collected the next day
9. washwashed with diethyl ether