HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 2-Chloro-6-anilino-9-isopropylpurine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 2,6-dichloro-9-(propan-2-yl)-9H-purine | HCID 11218490 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Chloro-6-anilino-9-isopropylpurine | HCID 21951839 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
2,6-dichloro-9-isopropylpurine (0.019 g, 0.081 mmol) was dissolved in butanol (0.5 ml) and aniline (0.044 ml, 0.244 mmol) was added. The reaction mixture was heated to 120° C. for 10 hr, cooled, diluted with EtOAc and washed 3 times with water. The mixture was dried over MgSO4 and concentrated to an off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06790958B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-0757d74d3aac49bf858eaab75e61e022 |
| Source note | uspto-grants-2004_09 |