1-(Bromomethyl)-3-chloro-2-methylbenzene → 8-(3-Bromo-2-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine

HRID 1006665Notes

Reaction equation

HRID 1006665 reaction equation
Cl[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[CH2:4]Br.ClC1C(C)=C(C=CC=1)C[Br:16].[NH2:21][C:22]1[C:23]2[N:24]([C:28]([CH3:32])=[C:29]([CH3:31])[N:30]=2)[CH:25]=[CH:26][CH:27]=1>>[Br:16][C:2]1[C:3]([CH3:4])=[C:6]([CH:7]=[CH:8][CH:9]=1)[CH2:10][NH:21][C:22]1[C:23]2[N:24]([C:28]([CH3:32])=[C:29]([CH3:31])[N:30]=2)[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 105130911-(Bromomethyl)-3-chloro-2-methylbenzeneHCID 218739802,3-Dimethylimidazo[1,2-a]pyridin-8-amineHCID 226726062-(Bromomethyl)-1-chloro-3-methylbenzene

Product 1

HCID 226725958-(3-Bromo-2-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine

Procedure

Example 1.34 and 1.35 are prepared from a mixture of 2-chloro-6-methylbenzylbromide and 3-chloro-2-methylbenzylbromide. The yields are referred to 8-amino-2,3-dimethylimidazo[1,2-a]pyridine.

Sources & evidence

ORD record
ord-5fb475b7aa2745e1b757236c4bf73e84
Source dataset
uspto-grants-2004_09
Patent number
US06790960B2

Reaction notes

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