反应详情

2-chloromethyl-8-(2,6-dimethylbenzylamino)-3-methylimidazo[1,2-a]pyridine (0.2 g, 0.64 mmol) and sodium methanethiolate (0.1 g, 1.3 mmol) were added to acetonitrile (10 ml) and stirred for 4 h. at room temperature. The solvent was evaporated under reduced pressure and to the residue were added methylene chloride and water. The organic layer was separated, dried (Na2SO4) and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using diethyl ether:petroleum ether (1:2) as eluent and crystallization from diethyl ether:petroleum ether (1:2) gave 0.05 g (24%) of the desired product.

1. customThe solvent was evaporated under reduced pressure and to the residue
2. additionwere added methylene chloride and water
3. customThe organic layer was separated
4. dry with materialdried (Na2SO4)
5. customevaporated under reduced pressure
6. customPurification of the residue by column chromatography on silica gel
7. customcrystallization from diethyl ether:petroleum ether (1:2)