反应详情

2-chloromethyl-8-(2,6-dimethylbenzylamino)-3-methylimidazo[1,2-a]pyridine (0.3 g, 0.96 mmol) was solved in methanol (20 ml) and stirred for 20 h. at room temperature and refluxed for 20 min. The solvent was evaporated under reduced pressure and the residue was dissolved in methylene chloride and washed with a bicarbonate solution. The organic layer was separated, dried (Na2SO4) and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using diethyl ether:petroleum ether (2:1) as eluent and crystallization from diethyl ether:petroleum ether (2:1) gave 0.13 g (44%) of the desired product.

1. temperaturerefluxed for 20 min
2. customThe solvent was evaporated under reduced pressure
3. dissolutionthe residue was dissolved in methylene chloride
4. washwashed with a bicarbonate solution
5. customThe organic layer was separated
6. dry with materialdried (Na2SO4)
7. customevaporated under reduced pressure
8. customPurification of the residue by column chromatography on silica gel
9. customcrystallization from diethyl ether:petroleum ether (2:1)