HCID 22672861, compound → HCID 22672855, compound

Participants

Reaction Steps

A mixture of the title F compound, 2-benzyloxy-5-(2,6-dimethyl-4-nitrophenoxy)-N-(2,2-dimethylpropyl)benzenesulfonamide (1.22 g, 2.45 mmol) and palladium on activated carbon (10 wt. %; 250 mg) in 40 mL of THF is stirred under hydrogen atmosphere (H2, 1 atm) for 8 h. The catalyst is removed by vacuum filtration through celite, washed with THF and the combined filtrate and washings are concentrated. The residue is suspended in CH2Cl2 and the product is collected by vacuum filtration, washed with CH2Cl2 and dried to give 5-(4-amino-2,6-dimethyl-phenoxy)-2-hydroxy-N-(2,2-dimethylpropyl)benzenesulfonamide: NMR (DMSO-d6) 0.80 (s, 9H), 1.90 (s, 6H), 2.55 (d, 2H, J=7.5), 4.90 (br s, 2H), 6.31 (s, 2H), 6.87 (br s, 1H), 6.93 (br s, 2H), 6.97 (t, 1H, J=7.5), 10.13 (s, 1H).

Provenance & Evidence