HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → (3-Bromopropoxy)(tert-butyl)dimethylsilane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-[(Tert-butyldimethylsilyl)oxy]propan-1-ol | HCID 4077791 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-Bromopropoxy)(tert-butyl)dimethylsilane | HCID 607486 | 86.7% |
Reaction Conditions
| Temperature | -25 °C |
|---|
Reaction Steps
5.44 g of tetrabromomethane and 4.30 g of triphenyl-phosphine were added to a solution of 2.5 g of the product of Step A in 27 ml of methylene chloride cooled down to −25° C. The reaction solution was stirred for 90 minutes at 0° C. and then was chromatographed on silica (eluant:ethyl acetate-cyclohexane 1-9) to obtain 2.885 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06790971B1 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-8c2b5045e16048d181c7dd25a20290b9 |
| Source note | uspto-grants-2004_09 |