2,5-Difluorobenzaldehyde → HCID 86584841, compound

HRID 1006793Notes

Reaction equation

HRID 1006793 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][C@H:14]([S:16]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:13][C@H:12]1[CH2:36][NH2:37])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:38][C:39]1[CH:46]=[CH:45][C:44]([F:47])=[CH:43][C:40]=1[CH:41]=O>>[CH2:1]([O:8][C:9]([N:11]1[CH2:15][C@H:14]([SH:16])[CH2:13][C@H:12]1[CH2:36][NH:37][CH2:41][C:40]1[CH:43]=[C:44]([F:47])[CH:45]=[CH:46][C:39]=1[F:38])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1376632,5-DifluorobenzaldehydeHCID 69431427HCID 69431427, compound

Product 1

HCID 86584841HCID 86584841, compound

Procedure

(2S,4R)-2-aminomethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid benzyl ester and 2,5-difluorobenzaldehyde and subsequent cleavage of the trityl protecting group analogously to reductive amination and deprotection gave (2S,4R)-2-[(2,5-difluoro-benzylamino)-methyl]-4-mercapto-pyrrolidine-1-carboxylic acid benzyl ester as colorless oil, MS: 393 (MH+).

Sources & evidence

ORD record
ord-0c659fa1f0fc4a298ec8ee6a622b4471
Source dataset
uspto-grants-2004_09
Patent number
US06790860B2

Reaction notes

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