HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylstyrene → (3R,5S)-1-methanesulfonyl-5-(3-phenyl-propoxymethyl)-pyrrolidine-3-thiol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylstyrene | HCID 98116 | — |
| Reactant | (2S,4R)-(1-methanesulfonyl-4-tritylsulfanyl-pyrrolidin-2-yl)-methanol | HCID 69433309 | — |
| Reactant | TFA triethylsilane | HCID 131722655 | — |
| Product | (3R,5S)-1-methanesulfonyl-5-(3-phenyl-propoxymethyl)-pyrrolidine-3-thiol | HCID 86584849 | — |
Reaction Steps
(2S,4R)-(1-methanesulfonyl-4-tritylsulfanyl-pyrrolidin-2-yl)-methanol with 3-bromo-1-phenyl-1-propene, followed by hydrogenation (17 h) and TFA/triethylsilane deprotection (Method 3) gave (3R,5S)-1-methanesulfonyl-5-(3-phenyl-propoxymethyl)-pyrrolidine-3-thiol, MS: 329 (M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06790860B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-ce10c176979244f68c8670fed21e6f73 |
| Source note | uspto-grants-2004_09 |