HCID 69431418, compound → HCID 86584857, compound

HRID 1006849Notes

Reaction equation

HRID 1006849 reaction equation
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][N:14]([S:16]([C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=2)(=[O:18])=[O:17])[CH2:13][CH:12]([CH2:29]O)[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]([OH:34])(=[S:33])[CH3:32]>>[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][N:14]([S:16]([C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=2)(=[O:17])=[O:18])[CH2:13][CH:12]([CH2:29][S:33][C:31](=[O:34])[CH3:32])[CH2:11]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69431418HCID 69431418, compoundHCID 178418634HCID 178418634, compound

Product 1

HCID 86584857HCID 86584857, compound

Procedure

(3SR,5RS)-[5-Benzyloxymethyl-1-(naphthalene-2-sulfonyl)-piperidin-3-yl]-methanol (1.35 g) was reacted with thioacetic acid (see Mitsunobu reaction described in Example 17) to obtain thioacetic acid (3SR,5RS)—S-[5-benzyloxymethyl-1-(naphthalene-2-sulfonyl)-piperidin-3-ylmethyl] ester (0.92 g) as a syrup, MS: 484 (MH+).

Sources & evidence

ORD record
ord-19dff4c83e51436188964f366ea90553
Source dataset
uspto-grants-2004_09
Patent number
US06790860B2

Reaction notes

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