Hydrochloric Acid → HCID 22671560, compound

Participants

Reaction Steps

To a solution of LiAlH4 (0.23 mmol, 1 M in THF) in Et2O (6 ml) was added a suspension of thioacetic acid (3RS,4RS)—S-(4-benzyloxymethyl-1-methanesulfonyl-pyrrolidin-3-ylmethyl) ester (75.5 mg, 0.21 mmol) in Et2O. The mixture was stirred at RT for 30 min and refluxed for 2 h. After cooling to r.t., water and 1 M aqueous HCl were added. The organic phase was dried and evaporated to give 63 mg (95%) of [(3RS,4RS)-4-benzyloxymethyl-1-methanesulfonyl-pyrrolidin-3-yl]-methanethiol as a colorless oil, MS: 333 (M+NH4)+.

Provenance & Evidence