HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Morpholine → HCID 22503318, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Morpholine | HCID 8083 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 4-Fluorobenzonitrile | HCID 14517 | — |
| Edukt | N-methyl-2-toluamide | HCID 75111 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | HCID 22503318 | HCID 22503318 | 41,5% |
Reaktionsschritte
4-(4-Morpholinyl)benzonitrile obtained by reacting 4-fluorobenzonitrile (10.89 g) and morpholine (7.84 g) in the presence of potassium carbonate (12.42 g) in dimethyl sulf oxide (45 ml) was reacted with N-methyl-o-toluamide (8.019 g) according to Example 10-1, to give 6.840 g of 3-[4-(4-morpholinyl)phenyl]isoquinolin-1-one.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06790844B2 |
| Quelldatensatz | uspto-grants-2004_09 |
| ORD ID | ord-bfb04973d50f447d9915484061949813 |
| Quellennotiz | uspto-grants-2004_09 |