N-methyl-2-toluamide → 3-(4-(n-Butyl)phenyl]isoquinolin-1-one

HRID 1006962Notes

Reaction equation

HRID 1006962 reaction equation
[CH3:1][NH:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[CH2:12]([C:16]1[CH:23]=[CH:22][C:19](C#N)=[CH:18][CH:17]=1)[CH2:13][CH2:14][CH3:15]>>[CH2:12]([C:16]1[CH:23]=[CH:22][C:19]([C:1]2[NH:2][C:3](=[O:11])[C:4]3[C:5]([CH:10]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)=[CH:18][CH:17]=1)[CH2:13][CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 75111N-methyl-2-toluamideHCID 1407304-Butylbenzonitrile

Product 1

HCID 225028893-(4-(n-Butyl)phenyl]isoquinolin-1-oneYield 31.5%

Procedure

According to the method of Example 10-1, N-methyl-2-methylbenzamide (4.28 g) and 4-(n-butyl)benzonitrile (4.57 g) were reacted, to give 3-[4-(n-butyl)phenyl]isoquinolin-1-one (2.51 g).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-572fb985bbc54b5fb21fbfd73acdfa36
Source dataset
uspto-grants-2004_09
Patent number
US06790844B2

Reaction notes

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