N-methyl-2-toluamide → HCID 22502873, compound

HRID 1006964Notes

Reaction equation

HRID 1006964 reaction equation
[CH3:1][NH:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].C([C:14]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][N:15]=1)#N>>[CH3:21][O:20][C:18]1[CH:17]=[CH:16][N:15]=[C:14]([C:1]2[NH:2][C:3](=[O:11])[C:4]3[C:5]([CH:10]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:19]=1

Participants

3

Reactant 2

HCID 75111N-methyl-2-toluamideHCID 134151564-Methoxypyridine-2-carbonitrile

Product 1

HCID 22502873HCID 22502873, compoundYield 29.9%

Procedure

According to the method of Example 10-1, N-methyl-2-methylbenzamide (4.96 g) and 2-cyano-4-methoxypyridine (4.46 g) were reacted, to give 3-(4-methoxypyridin-2-yl)isoquinolin-1-one (2.51 g).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-e9a267a61a274518b74c231b65082445
Source dataset
uspto-grants-2004_09
Patent number
US06790844B2

Reaction notes

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